SB-408124
SB-408124 is a elective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). A critical role for the orexin-1 receptor (OX1R) in complex emotional behavior is emerging, such as overactivation of the OX1R pathway being associated with panic or anxiety states.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD401 |
| CAS # | 288150-92-5 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | SB-408124; SB 408124; SB408124 free base |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C19H18F2N4O |
| Exact Mass | 356.1449 |
| Molecular Weight | 356.3768 |
| Elemental Analysis | C, 64.04; H, 5.09; F, 10.66; N, 15.72; O, 4.49 |
| IUPAC/Chemical Name | N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]urea |
| InChi Key | JTARFZSNUAGHRB-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C19H18F2N4O/c1-11-8-17(15-9-12(20)10-16(21)18(15)22-11)24-19(26)23-13-4-6-14(7-5-13)25(2)3/h4-10H,1-3H3,(H2,22,23,24,26) |
| SMILES Code | O=C(NC1=CC=C(N(C)C)C=C1)NC2=CC(C)=NC3=C(F)C=C(F)C=C23 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |