(S,R,S)-AHPC
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-125845-1 g |
| CAS # | 1448297-52-6 |
| Pricing | 1 g, inquire |
| Biological Activity | (S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1]. |
| Synonyms | VH032-NH2; VHL ligand 1 |
| MWt | 430.56 |
| Formula | C₂₂H₃₀N₄O₃S |