Lamin B1 (E6M5T) Rabbit Antibody

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Supplier CD BioSciences
Product # AMA-0162
Pricing 100 μL, Inquire
Product Category Antibodies
Application WB, IHC
Product Usage Information Dilution Western Blotting (1:1000); Immunohistochemistry (1:500-1:2000)
Reactivity Human, Monkey, Rat
Host Rabbit
Source/Isotype Rabbit IgG
MW (Target) 68 kDa
Storage Store at -20°C.
Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg455 of human lamin B1 protein.
Background Lamins are nuclear membrane structural components that are important in maintaining normal cell functions, such as cell cycle control, DNA replication, and chromatin organization. Lamins have been subdivided into types A and B. Type-A lamins consist of lamin A and C, which arise from alternative splicing of the lamin A gene LMNA. Lamin A and C are cleaved by caspases into large (41-50 kDa) and small (28 kDa) fragments, which can be used as markers for apoptosis. Type-B lamins consist of lamin B1 and B2, encoded by separate genes. Lamin B1 is also cleaved by caspases during apoptosis. Research studies have shown that duplication of the lamin B1 gene LMNB1 is correlated with pathogenesis of the neurological disorder adult-onset leukodystrophy.
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