JNK Antibody
| Supplier | CD BioSciences |
|---|---|
| Product # | AMA-0214 |
| Pricing | , Inquire |
| Product Category | Antibodies |
| Application | WB, IHC |
| Product Usage Information Dilution | Western Blotting (0.5-4 µg/mL); Immunohistochemistry (10-20 µg/mL) |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Gene ID | 5599 |
| Source/Isotype | Rabbit IgG |
| Storage | Store at -20°C. |
| Purification | Affinity purified |
| Background | The JNK pathway is activated by largely distinct stimuli including inflammatory cytokines (such as TNF-α and IL-1), UV light, inhibitors of protein synthesis and osmotic stress. Activated MEKK1 phosphorylates SEK1 (also known as MKK4), which in turn activates SAPK (also known as JNK). JNK binds tightly to the N-terminal region of c-Jun and ATF-2, and phosphorylates c-Jun at Ser63 and Ser73 and ATF-2 at Thr69 and Thr71. |