Recombinant Human TNFSF18 protein, Fc-tagged

Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid-induced TNF-related ligand (GITRL or GITR Ligand), Activation-inducible TNF-related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18/GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18/GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.

• Supplier: Creative Biomart
• Product #: TNFSF18-37H