Brevetoxin-3
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-12545 |
| CAS # | 85079-48-7 |
| Pricing | inquire |
| Biological Activity | Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain)[1]. Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation[2]. |
| Synonyms | PbTx-3 |
| MWt | 897.1 |
| Formula | C₅₀H₇₂O₁₄ |