LIM Domain Kinase 2 (LIMK2) Antibody
LIMK2 Antibody is a Rabbit Polyclonal antibody against LIMK2. There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.
Supplier | Abbexa Ltd. |
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Product # | abx004143-200UL |
Pricing | 200 µl USD $696.0 |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Host | Rabbit |
Tested Applications | WB, IF/ICC |
UniProt Primary AC | P53671 |
Dry Ice | No |
Availability | Shipped within 5-10 working days. |
Note | This product is for research use only. |