Myristic Acid

Myristic acid occurs as an oily white crystalline solid with a faint odor.

• Supplier: CD Formulation
• Product #: PE-0554
• product1: Excipients for Liquid Dosage Form
• Molecular Formula: C14H28O2
• Molecular Weight: 228.37
• Applications: Myristic acid is used in oral and topical pharmaceutical formulations. Myristic acid has been evaluated as a penetration enhancer in melatonin transdermal patches in rats and bupropion formulations on human cadaver skin. Further studies have assessed the suitability of myristic acid in oxymorphone formulations and clobetasol 17-propionate topical applications. Furthermore, polyvinyl alcohol substituted with myristic acid (as well as other fatty acids) at different substitution degrees has been used for the preparation of biodegradable microspheres containing progester one or indomethacin.
• Safety: Myristic acid is used in oral and topical pharmaceutical formulations and is generally regarded as nontoxic and nonirritant at the levels employed as an excipient. However, myristic acid is reported to be an eye and skin irritant at high levels and is poisonous by intravenous administration. Mutation data have also been reported. LD50 (mouse, IV): 0.043 g/kg LD50 (rat, oral): >10 g/kg
• Incompatibilities: Myristic acid is incompatible with strong oxidizing agents and bases.
• Synonyms: Edenor C14 98-100; n-tetradecanoic acid; 1-tridecanecarboxylic acid
• CAS Number: 544-63-8
• Category: Emulsifying Agents; Skin Penetrant; Tablet and Capsule Lubricant
• UNII: 0I3V7S25AW
• Chemical Name: Tetradecanoic acid
• Grade: Pharmceutical Excipients
• Administration route: Oral
• Dosage Form: Oral capsules
• Stability and Storage Conditions: The bulk material should be stored in a well-closed container in a cool, dry, place.
• Source and Preparation: Myristic acid occurs naturally in nutmeg butter and in most animal and vegetables fats. Synthetically, it may be prepared by electrolysis of methyl hydrogen adipate and decanoic acid or by Maurer oxidation of myristyl alcohol.