Ulotaront
Ulotaront, also known as SEP-363856, and SEP-856, is a TAAR1/5-HT1A agonist. Ulotaront interacts with a small, common set of conserved residues within the TAAR1 and 5HT1A ligand-binding domain. Ulotaront is a compound of high solubility, high permeability, and low binding to plasma proteins. Ulotaront metabolism is mediated via both NADPH-dependent and NADPH-independent pathways, with CYP2D6 as the major metabolizing enzyme. Ulotaront is a promising agent for the treatment of schizophrenia with an apparent benign safety profile, which might provide a much-needed new and different treatment option for various domains of schizophrenia.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1744 |
| CAS # | 1310426-33-5 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | Ulotaront; SEP-856; SEP856; SEP 856; SEP-363856; SEP 363856; SEP363856; |
| Product Category | Lab-use Small Molecule Drugs |
| IUPAC/Chemical Name | (S)-1-(4,7-dihydro-5H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine |
| InChi Key | ABDDQTDRAHXHOC-QMMMGPOBSA-N |
| InChi Code | InChI=1S/C9H13NOS/c1-10-6-8-9-7(2-4-11-8)3-5-12-9/h3,5,8,10H,2,4,6H2,1H3/t8-/m0/s1 |
| SMILES Code | CNC[C@H]1C2=C(C=CS2)CCO1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | To be determined |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | To be determined |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Depression |