AR-M1896
AR-M1896 is a synthetic peptide fragment of the neuropeptide galanin and an agonist of the galanin-2 (GAL2) receptor (EC50 = 9.32 nM in a fluorescence imaging plate reader assay). It selectively binds to the GAL2 receptor (IC50 = 1.76 nM for the rat receptor) over the GAL1 receptor (IC50 = 879 nM for the human receptor) but does also bind to the GAL3 receptor (Ki = 271 nM for the rat receptor). Intracerebroventricular administration of AR-M1896 (1 nmol/animal) decreases immobility in the forced swim test in rats. It also reduces the hind paw mechanical pain threshold and increases the hind paw cold sensitivity threshold in rats.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD065 |
| CAS # | unknown |
| Pricing | Customizable size, Inquiry |
| Synonym | AR-M1896; ARM1896; AR M1896; Gal(2-11)-NH2; Gal(2-11)NH2; Gal(2-11) NH2; WTLNSAGYLL-NH2; WTLNSAGYLLNH2; WTLNSAGYLL NH2; Galanin (2-11) amide TFA; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C56H82F3N13O16 |
| Molecular Weight | 1250.3422 |
| Elemental Analysis | C, 53.79; H, 6.61; F, 4.56; N, 14.56; O, 20.47 |
| IUPAC/Chemical Name | (S)-2-((S)-2-((2S,3R)-2-((S)-2-amino-3-(1H-indol-3-yl)propanamido)-3-hydroxybutanamido)-4-methylpentanamido)-N1-((2S,5S,11S,14S,17S)-17-carbamoyl-1-hydroxy-11-(4-hydroxybenzyl)-14-isobutyl-5,19-dimethyl-3,6,9,12,15-pentaoxo-4,7,10,13,16-pentaazaicosan-2-yl)succinamide 2,2,2-trifluoroacetate |
| InChi Key | ILTGGRBAWMAFAK-DQGGFSSQSA-N |
| InChi Code | InChI=1S/C54H81N13O14.C2HF3O2/c1-26(2)17-37(46(57)73)62-49(76)38(18-27(3)4)63-51(78)40(20-31-13-15-33(70)16-14-31)61-44(72)24-59-47(74)29(7)60-53(80)42(25-68)66-52(79)41(22-43(56)71)64-50(77)39(19-28(5)6)65-54(81)45(30(8)69)67-48(75)35(55)21-32-23-58-36-12-10-9-11-34(32)36;3-2(4,5)1(6)7/h9-16,23,26-30,35,37-42,45,58,68-70H,17-22,24-25,55H2,1-8H3,(H2,56,71)(H2,57,73)(H,59,74)(H,60,80)(H,61,72)(H,62,76)(H,63,78)(H,64,77)(H,65,81)(H,66,79)(H,67,75);(H,6,7)/t29-,30+,35-,37-,38-,39-,40-,41-,42-,45-;/m0./s1 |
| SMILES Code | N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(N[C@@H](CC(C)C)C(N)=O)=O)CC(C)C)=O)=O)=O)C)=O)CO)=O)CC(N)=O)=O)CC(C)C)=O)[C@@H](C)O)=O.OC(C(F)(F)F)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | To be determined |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | To be determined |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Depression |
| Availability | 2 Weeks |