pestivirus NS3 polyprotein peptidase

The polyprotein of noncytopathogenic pestiviruses is cleaved co- and post-translationally into at least 11 proteins (Npro, C, Erns, E1, E2, p7, NS2-3, NS4A, NS4B, NS5A, and NS5B). The genomes of cytopathogenic pestivirus strains express at least one additional protein, called NS3 (p80). This enzyme, which resides in the N-terminal region of NS3 (nonstructural protein 3), is essential for generation of its own C-terminus and for processing of the downstream cleavage sites, leading to the release of the pestivirus nonstructural proteins NS4A, NS4B, NS5A and NS5B. Belongs in peptidase family S31.

• Supplier: Creative Enzymes
• Product #: EXWM-4108