Chelidonic Acid
Chelidonic acid is a pyran that has been found in C. majus and has diverse biological activities. It inhibits rat brain glutamate decarboxylase. Chelidonic acid reduces serum IL-6 and TNF-α levels, colonic COX-2 and prostaglandin E2 levels, and the disease activity index score in a mouse model of ulcerative colitis induced by dextran sulfate sodium. It inhibits ovalbumin challenge-induced decreases in spleen IFN-γ levels and increases in serum, spleen, and nasal mucosa IgE levels, spleen IL-4 levels, and nasal mucosa eosinophil and mast cell infiltration in a mouse model of ovalbumin-sensitized allergic rhinitis when administered at a dose of 2 mg/kg.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD702 |
| CAS # | 99-32-1 |
| Pricing | Customizable size, Inquiry |
| Synonym | Chelidonic Acid; NSC 3979; NSC3979; NSC-3979; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C7H4O6 |
| Exact Mass | 184.0008 |
| Molecular Weight | 184.103 |
| Elemental Analysis | C, 45.67; H, 2.19; O, 52.14 |
| IUPAC/Chemical Name | 4-oxo-4H-pyran-2,6-dicarboxylic acid |
| InChi Key | PBAYDYUZOSNJGU-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C7H4O6/c8-3-1-4(6(9)10)13-5(2-3)7(11)12/h1-2H,(H,9,10)(H,11,12) |
| SMILES Code | O=C1C=C(OC(C(O)=O)=C1)C(O)=O |
| Appearance | To be determined |
| Purity | >95% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |