Amitifadine HCl
Amitifadine the only drug ever clinically tested in Phase 3 for treating depression, is a triple reuptake inhibitor (TRI) that simultaneously interacts with human monoamine transporters (MATs) including hSERT, hNET and hDAT. This novel multi-target strategy improves drug efficacy and reduces the toxic side effects of drugs. However, the binding modes accounting for amitifadine's polypharmacological mode of action are still elusive, and extensive exploration of the amitifadine-target interactions between amitifadine and MATs is urgently needed.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD682 |
| CAS # | 410074-74-7 (HCl) |
| Pricing | Customizable size, Inquiry |
| Synonym | Amitifadine; DOV 21,947; EB 1010; Amitifadine HCl; Amitifadine hydrochloride |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C11H12Cl3N |
| Exact Mass | 227.0269 |
| Molecular Weight | 264.574 |
| Elemental Analysis | C, 49.94; H, 4.57; Cl, 40.20; N, 5.29 |
| IUPAC/Chemical Name | 3-Azabicyclo(3.1.0)hexane, 1-(3,4-dichlorophenyl)-, (1R,5S)- hydrochloride |
| InChi Key | KAGBHVBIOJBGBD-NINOIYOQSA-N |
| InChi Code | InChI=1S/C11H11Cl2N.ClH/c12-9-2-1-7(3-10(9)13)11-4-8(11)5-14-6-11;/h1-3,8,14H,4-6H2;1H/t8-,11+;/m1./s1 |
| SMILES Code | ClC1=CC=C([C@]23CNC[C@@]2([H])C3)C=C1Cl.[H]Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |