FR-194921
FR-194921 is a new potent, selective, and orally active antagonist for central adenosine A1 receptors. FR194921 showed potent and selective affinity for the adenosine A1 receptor without affinity for A2A and A3 receptors and did not show any species differences in binding affinity profile among human, rat, and mouse. FR194921 exerts both cognitive-enhancing and anxiolytic activity, suggesting the therapeutic potential of this compound for dementia and anxiety disorders.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD225 |
| CAS # | 202646-80-8 |
| Pricing | Customizable size, Inquiry |
| Synonym | FR-194921; FR 194921; FR194921. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C23H23N5O |
| Exact Mass | 385.19026 |
| Molecular Weight | 385.46 |
| Elemental Analysis | C, 71.67; H, 6.01; N, 18.17; O, 4.15 |
| IUPAC/Chemical Name | 3(2H)-Pyridazinone, 2-(1-methyl-4-piperidinyl)-6-(2-phenylpyrazolo(1,5-a)pyridin-3-yl)- |
| InChi Key | YHDRUTMZCJZJAL-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C23H23N5O/c1-26-15-12-18(13-16-26)28-21(29)11-10-19(24-28)22-20-9-5-6-14-27(20)25-23(22)17-7-3-2-4-8-17/h2-11,14,18H,12-13,15-16H2,1H3 |
| SMILES Code | O=C1C=CC(C2=C3C=CC=CN3N=C2C4=CC=CC=C4)=NN1C5CCN(C)CC5 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |