Stenoparib

Stenoparib is an oral, small-molecule ribozyme poly(ADP-ribose) polymerase (PARP) 1 and 2 inhibitor with potential anti-tumor activity. Upon administration, E7449 selectively binds to PARP 1 and 2, thereby preventing repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of single- and double-stranded DNA breaks and promotes genomic instability, ultimately leading to apoptosis. The PARP 1/2 inhibitor E7449 may enhance the cytotoxicity of DNA-damaging agents and radiation therapy. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins, thereby signaling and recruiting other proteins to repair damaged DNA.

• Supplier: Alfa Cytology
• Product #: BC0074