M8 B hydrochloride
M8 B hydrochloride is a selective and potent channel blocker of transient receptor potential melastatin 8 (TRPM8). It blocks cold-induced and icilin or methol-induced activation of rat, human, and murine TRPM8 channels. It displays no effect at other TRP channels with IC50 value of > 20 mM. It decreases deep body temperature in wild-type mice and rats but has no effect on body temperature in TRPM8 KO mice. It may be used to induce therapeutic hypothermia, which is an effective treatment in cardiac arrest.
| Supplier | BOC Sciences |
|---|---|
| Product # | 883976-12-3 |
| Pricing | Inquire |
| Cas | 883976-12-3 |
| Molecular Weight | 432.96 |
| Molecular Formula | C22H25N2O3SCl |
| Canonical SMILES | COC1=C(C=CC(=C1)CN(CCN)C(=O)C2=CC=CS2)OCC3=CC=CC=C3.Cl |