Infigratinib, Free Base (BGJ398, NVP-BGJ398, CAS 872511-34-7)

LC Laboratories' Product Number I-1500 - Infigratinib, Free Base (BGJ398, NVP-BGJ398, CAS 872511-34-7), >99% - for research use only. Infigratinib, also known as BGJ398, is a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinases. It was shown to have significant antitumor activity in RT112 bladder cancer xenografts models that overexpress wild-type FGFR3. This research compound is the free base form of infigratinib. We also offer the phosphate salt form; please see Infigratinib, Phosphate Salt, Cat. No. I-1533. Infigratinib inhibited FGFR1, FGFR2, and FGFR3 with single digit nM IC50 potencies in biochemical and cellular autophosphorylation assays. It significantly blocked proliferation of cancer cell lines bearing FGF/FGFR genetic alterations across various cancer types. Infigratinib inhibited FGFR2 signaling, induced cell-cycle arrest, and significantly increased apoptosis in FGFR2-mutant lines. It inhibited the proliferation of cancer cell lines with activating FGFR2 mutations (S252W, N550K) more effectively compared to their FGFR2 wild-type counterparts in vitro. It also blocked the growth of FGFR2-mutated endometrial cancer xenograft models more effectively compared to the wild type tumors in vivo. This infigratinib product is the free base, whose CAS number is given above. The CAS number of Infigratinib, Phosphate Salt is 1310746-10-1. Related CAS numbers: 1310746-12-3 for the methanesulfonate salt (1:1); 1310746-11-2 for the monohydrate (1:1); 1310746-17-8 for the acetate salt (1:1); 1310746-15-6 for the hydrochloride (1:1) salt; 1310746-16-7 for the hydrochloride dihydrate (1:1:2) salt; 1310746-20-3 for the fumarate (1:1) salt; 1310746-19-0 for the citrate (1:1) salt; and 1310746-18-9 for the benzoate (1:1) salt. Another CAS number previously assigned to Infigratinib, Free Base, namely 1430224-87-5, has been deleted by CAS and is no longer in use.

• Supplier: LC Laboratories
• Product #: I-1500
• Sku #: I-1500_5mg