Shugoshin 2 (SGO2) Antibody

Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.
Supplier Abbexa Ltd.
Product # abx031385-80UL
Pricing 80 µl USD $326.25
Clonality Polyclonal
Conjugation Unconjugated
Host Rabbit
Tested Applications ELISA, WB
UniProt Primary AC Q562F6
Dry Ice No
Availability Shipped within 5-10 working days.
Note This product is for research use only.
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