Fasudil, Monohydrochloride Salt (Eril, HA1077, AT-877, 1-(5-Isoquinolinesulfonyl)homopiperazine, CAS 105628-07-7), >99%

LC Laboratories' Product Number F-4660 - Fasudil, Monohydrochloride Salt (Eril, HA1077, AT-877, 1-(5-Isoquinolinesulfonyl)homopiperazine), >99% - for research use only. Nomenclature: Two names have been widely used for this compound, HA-1077 and Fasudil, and these names have been variously and inconsistently applied to the free base (a form that LC Labs does not sell), the monohydrochloride salt and the dihydrochloride salt forms. For many years LC Labs has sold the dihydrochloride salt under the name HA-1077, Dihydrochloride Salt, Cat. No. H-2330. For historical reasons and for continuity, we have elected to continue using the HA-1077 name for our dihydrochloride salt product, even though we recently introduce the monohydrochloride salt form under the name Fasudil, Monohydrochloride Salt, Cat. No. F-4660, as described on this page. The monohydrochloride salt is the form used to prepare formulations of this drug for clinical use. Note that the solubility properties of the mono- and di-HCl salts are different. Kinase inhibitor; has antivasospastic properties. This monohydrochloride salt form is the active ingredient in drug formulations marketed in Japan to treat cerebral vasospasm following surgery for subarachnoid hemorrhage and associated cerebral ischemic symptoms. Also, the monohydrochloride form has been or presently is in human clinical trials for treatment of acute cerebral thrombosis, subarachnoid hemorrhage, and angina pectoris. Related CAS numbers: 103745-39-7 for the fasudil free base and 203911-27-7 for HA-1077 dihydrochloride salt.

• Supplier: LC Laboratories
• Product #: F-4660
• Sku #: F-4660_1g