Cariprazine HCl
Cariprazine, also known as RGH-188 and MP-214, is an antipsychotic drug received FDA approval on September 17, 2015. Cariprazine acts as a D2 and D3 receptor partial agonist, with high selectivity towards the D3 receptor. Action on the dopaminergic systems makes it also potentially useful as an add-on therapy in major depressive disorder. Cariprazine is approved for schizophrenia and bipolar disorder. It has also been investigated as a potential adjunct in treatment-resistant major depressive disorder.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD542 |
| CAS # | 1083076-69-0 (HCl) |
| Pricing | Customizable size, Inquiry |
| Synonym | RGH-188; RGH188; RGH 188; MP-214; MP 214; MP214; Cariprazine. trade name Vraylar; Cariprazine HCl |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C21H33Cl3N4O |
| Exact Mass | 426.1953 |
| Molecular Weight | 463.872 |
| Elemental Analysis | C, 54.38; H, 7.17; Cl, 22.93; N, 12.08; O, 3.45 |
| IUPAC/Chemical Name | 3-((1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)-1,1-dimethylurea hydrochloride |
| InChi Key | GPPJWWMREQHLQT-BHQIMSFRSA-N |
| InChi Code | InChI=1S/C21H32Cl2N4O.ClH/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23;/h3-5,16-17H,6-15H2,1-2H3,(H,24,28);1H/t16-,17-; |
| SMILES Code | O=C(N[C@H]1CC[C@H](CCN2CCN(C3=CC=CC(Cl)=C3Cl)CC2)CC1)N(C)C.[H]Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Schizophrenia |
| Availability | 2 Weeks |