VU6012962
VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 (mGlu7) negative allosteric modulator (NAM) that achieves exposure in cerebral spinal fluid (CSF) 2.5x above the in vitro IC50 at minimum effective doses (MEDs) of 3 mg/kg in preclinical anxiety models.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD448 |
| CAS # | 2313526-86-0 |
| Pricing | Customizable size, Inquiry |
| Synonym | VU6012962; VU-6012962; VU 6012962; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C21H19F3N4O4 |
| Exact Mass | 448.1358 |
| Molecular Weight | 448.4022 |
| Elemental Analysis | C, 56.25; H, 4.27; F, 12.71; N, 12.50; O, 14.27 |
| IUPAC/Chemical Name | N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide |
| InChi Key | IQNLJJLZIVCGFI-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C21H19F3N4O4/c1-30-19-8-14(4-7-18(19)31-10-13-2-3-13)20(29)27-16-9-15(32-21(22,23)24)5-6-17(16)28-12-25-11-26-28/h4-9,11-13H,2-3,10H2,1H3,(H,27,29) |
| SMILES Code | O=C(NC1=CC(OC(F)(F)F)=CC=C1N2N=CN=C2)C3=CC=C(OCC4CC4)C(OC)=C3 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |