1-Naphthohydroxamic acid

Supplier MedChemExpress
Product # HY-130538-10 mM * 1 mL
CAS # 6953-61-3
Pricing 10 mM * 1 mL, USD $72.0
Biological Activity 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity[1][2].1-Naphthohydroxamic acid can induce tubulin acetylation[3].
Purity ≥98.0%
MWt 187.19
Formula C₁₁H₉NO₂
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