1-Naphthohydroxamic acid
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-130538-10 mM * 1 mL |
| CAS # | 6953-61-3 |
| Pricing | 10 mM * 1 mL, USD $72.0 |
| Biological Activity | 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity[1][2].1-Naphthohydroxamic acid can induce tubulin acetylation[3]. |
| Purity | ≥98.0% |
| MWt | 187.19 |
| Formula | C₁₁H₉NO₂ |