SRA880 malonate
SRA880 is a non-peptide somatostatin sst(1) receptor antagonist. SRA880 displayed significantly lower affinity for the other human recombinant somatostatin receptors ( pK(d) < or = 6.0) or a wide range of neurotransmitter receptors, except for the human dopamine D4 receptors. SRA880 positively modulates release of endogenous SRIF, was found to synergize with imipramine in causing antidepressant-like effects in the tail suspension test.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1175 |
| CAS # | 573984-99-3 (malonate) |
| Pricing | Customizable size, Inquiry |
| Synonym | NVP-SRA880; NVP SRA880; NVPSRA880; NVP-SRA 880; NVP-SRA-880; SRA880; Obelin; SRA-880; SRA 880; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C29H36N4O8 |
| Molecular Weight | 568.62 |
| Elemental Analysis | C, 61.26; H, 6.38; N, 9.85; O, 22.51 |
| IUPAC/Chemical Name | [(3R,4aR,10aR)-6-Methoxy-1-methyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinolin-3-yl]-[4-(4-nitrophenyl)piperazin-1-yl]methanone Malonate |
| InChi Key | ACSWUHCQQFGYBZ-GIEJAJRFSA-N |
| InChi Code | InChI=1S/C26H32N4O4.C3H4O4/c1-27-17-20(14-19-15-23-18(16-24(19)27)4-3-5-25(23)34-2)26(31)29-12-10-28(11-13-29)21-6-8-22(9-7-21)30(32)33;4-2(5)1-3(6)7/h3-9,19-20,24H,10-17H2,1-2H3;1H2,(H,4,5)(H,6,7)/t19-,20-,24-;/m1./s1 |
| SMILES Code | O=C([C@H]1CN(C)[C@]2([H])CC3=CC=CC(OC)=C3C[C@@]2([H])C1)N4CCN(C5=CC=C([N+]([O-])=O)C=C5)CC4.O=C(O)CC(O)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.03.00 |