Pinometostat (EPZ5676)
Pinometostat (EPZ5676) is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM in a cell-free assay, demonstrating >37,000-fold selectivity against all other PMTs tested, inhibits H3K79 methylation in tumor. Phase 1.
| Supplier | Selleck Chemicals |
|---|---|
| Product # | S7062 |
| Sku # | S7062-10mM/1mL |
| Pricing | 10mM/1mL, $287.00 |
Citations for this product:
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bioRxiv - Systems Biology 2021Quote: ... 10 mM pinometostat (Selleck Chemicals, S7062), 100 μM trametinib (Selleck Chemicals ...
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bioRxiv - Systems Biology 2023Quote: ... at a final concentration of 1uM and the DOT1L inhibitor pinometostat (Selleck Chemicals #S7062) at a final concentration of 4uM.