Activin A Receptor Type 1C (ACVR1C) Antibody
ACVR1C Antibody is a Rabbit Polyclonal antibody against ACVR1C. ACTR-IC (Activin receptor type 1C), also referred to as Activin receptor-like kinase 7 (ALK-7), is a type I serine/threonine kinase receptor. ACTA-IC contains an extracellular binding domain, an intracellular serine/threonine kinase domain preceded by a GS box and a transmembrane domain. It is expressed throughout the digestive and central nervous system and localizes to the cell surface. Four ACTR-IC transcripts are generated by alternative splicing. Transcript 1 is the functional full length receptor, transcript 2 lacks a complete receptor binding domain and transcripts 3 and 4 are soluble proteins that lack a transmembrane domain. ACTR-IC is a receptor for Activin AB, Activin B and Nodal. In pancreatic cells, ACTR-IC forms a complex with Activin receptor type IIB (ACTR-IIB). The kinase domain of ACTR-IC can induce Smad2 and Smad3 signalling pathways. In some cell lines, ACTR-IC overexpression induces apoptosis and inhibits proliferation.
Supplier | Abbexa Ltd. |
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Product # | abx000813-20UL |
Pricing | 20 µl USD $203.0 |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Host | Rabbit |
Tested Applications | WB, IHC |
UniProt Primary AC | Q8NER5 |
Dry Ice | No |
Availability | Shipped within 5-10 working days. |
Note | This product is for research use only. |