| Supplier |
CD BioSciences |
| Product # |
AMA-0274 |
| Pricing |
100 µL, Inquire
|
| Product Category |
Antibodies
|
| Application |
WB, IP, IF
|
| Product Usage Information Dilution |
Western Blotting (1:1000); Immunoprecipitation (1:100); Immunofluorescence (1:800-1:3200)
|
| Reactivity |
Human
|
| Host |
Rabbit
|
| Gene ID |
8493
|
| UniProt ID |
|
| Source/Isotype |
Rabbit IgG
|
| MW (Target) |
79 kDa
|
| Storage |
Store at -20°C. Do not aliquot the antibody.
|
| Purification |
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly383 of human WIP1 protein.
|
| Background |
Wild-type p53 induced phosphatase 1 (WIP1)/protein phosphatase magnesium-dependent 1 delta (ppm1d) is a member of the PP2C family of serine/threonine protein phosphatases. WIP1 was initially identified as a p53 target gene, induced in response to ionizing radiation. Studies have shown that WIP1 is overexpressed in human cancers and is involved in the regulation of multiple DNA damage signaling pathways. WIP1 functions in returning cells to a homeostatic state following DNA damage, as well as in maintaining p53-dependent homeostasis under non-stressed conditions. Researchers have shown that increased expression of WIP1 is associated with poor prognosis and lower survival rate in some human cancers. In contrast, overexpression of WIP1 in p53-negative tumor cells sensitizes them to chemotherapy-induced apoptosis while protecting normal tissue during treatment.
|