anti-CRH immunotoxin PFU 83 (IgG)-RTA
This immunotoxin was achieved by conjugating/fusing the Anti-CRH monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CRF neurons cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of Anorexia nervosa.
| Supplier | Creative Biolabs |
|---|---|
| Product # | AGTO-L007R |
| Pricing | Inquiry |
| Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
| Host | Rat |
| Target | CRH |
| Species Reactivity | Human |