Dorsomorphin
Dorsomorphin is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Dorsomorphin selectively inhibits the BMP type I receptors ALK2, ALK3 and ALK6. Dorsomorphin is used in promoting specific cell differentiation and inducing cancer cell line autophagy. For animal testing, the water-soluble S7306 Dorsomorphin (Compound C) 2HCl is recommended.
| Supplier | Selleck Chemicals |
|---|---|
| Product # | S7840 |
| Sku # | S7840-25mg |
| Pricing | 25mg, $297.00 |
Citations for this product:
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bioRxiv - Cell Biology 2023Quote: ... Dorsomorphin (S7840, Selleck Chemicals; 11967, Cayman Chemical) dissolved in DMSO was added to RPE-1 cells at the final concentration of 10 μM for 24 hours (66) ...