Xanomeline oxalate
Xanomeline is a muscarinic acetylcholine receptor agonist with reasonable selectivity for the M1 and M4 subtypes, though it is also known to act as a M5 receptor antagonist. It has been studied for the treatment of both Alzheimer's disease and schizophrenia, particularly the cognitive and negative symptoms, although gastrointestinal side effects led to a high drop-out rate in clinical trials. Despite this, xanomeline has been shown to have reasonable efficacy for the treatment of schizophrenia symptoms, and one recent human study found robust improvements in verbal learning and short-term memory associated with xanomeline treatment.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1762 |
| CAS # | 141064-23-5 (oxalate) |
| Pricing | Customizable size, Inquiry |
| Synonym | LY-246708; LY246708; LY 246708; Xanomeline; Memcor; NNC-110232; Hexyloxy-TZTP; HexyloxyTZTP. Xanomeline oxalate |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C16H25N3O5S |
| Exact Mass | 281.1562 |
| Molecular Weight | 371.452 |
| Elemental Analysis | C, 51.74; H, 6.78; N, 11.31; O, 21.54; S, 8.63 |
| IUPAC/Chemical Name | 3-(hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole oxalate |
| InChi Key | ZJOUESNWCLASJP-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C14H23N3OS.C2H2O4/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12;3-1(4)2(5)6/h8H,3-7,9-11H2,1-2H3;(H,3,4)(H,5,6) |
| SMILES Code | CN1CCC=C(C2=NSN=C2OCCCCCC)C1 |
| Appearance | White to off-white solid powder. |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |