PRIMA-1
PRIMA-1, named for p53 reactivation and induction of massive apoptosis, is an inhibitor of the growth of cell lines derived from various human tumor types in a mutant p53-dependent manner. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations. It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes.
| Supplier | BOC Sciences |
|---|---|
| Product # | 5608-24-2 |
| Pricing | Inquire |
| Cas | 5608-24-2 |
| Molecular Weight | 185.22 |
| Molecular Formula | C9H15NO3 |
| Canonical SMILES | C1CN2CCC1C(=O)C2(CO)CO |