(R)-(-)-Gossypol acetic acid
(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.
Supplier | Selleck Chemicals |
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Product # | S2812 |
Sku # | S2812-50mg |
Pricing | 50mg, $470.00 |