Mirdametinib (PD0325901)
Mirdametinib (PD0325901) is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 2.
| Supplier | Selleck Chemicals |
|---|---|
| Product # | S1036 |
| Sku # | S1036-1g |
| Pricing | 1g, $970.00 |
Citations for this product:
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bioRxiv - Cell Biology 2021Quote: ... and inhibitors for MEK (1 µM; PD0325901, Cat#S1036; Selleck Chemicals) and glycogen synthase kinase-3β (1 µM ...
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bioRxiv - Molecular Biology 2021Quote: ... 1 μM PD0325901 (S1036, Selleck Chemicals), and 3 μM CHIR99021 (SML0146 ...
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bioRxiv - Bioengineering 2020Quote: ... 10 nM PD0325901 (MEK1/2 inhibitor; Selleck Chemicals # S1036), 1 μM SP600125 (pan-JNK inhibitor ...
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bioRxiv - Developmental Biology 2021Quote: ... a homemade version of the N2B27 medium was prepared based on previous reports (Ying et al, 2008) with additional modifications reported in (Hayashi & Saitou, 2013) containing two chemical inhibitors 0.4 µM PD032591 (Selleck Chemicals, S1036) and 3 µM CHIR99021 (SML1046 ...
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bioRxiv - Genetics 2023Quote: ... 0.4 µM PD0325901 (Selleck Chemicals, S1036) and LIF 1,000 U/ml (ORF Genetics ...