[heparan sulfate]-glucosamine 3-sulfotransferase 1

This enzyme differs from the other [heparan sulfate]-glucosamine 3-sulfotransferases [EC 2.8.2.29 ([heparan sulfate]-glucosamine 3-sulfotransferase 2) and EC 2.8.2.30 ([heparan sulfate]-glucosamine 3-sulfotransferase 3)] by being the most selective for a precursor of the antithrombin-binding site. It has a minimal acceptor sequence of: → GlcNAc6S→ GlcA→ GlcN2S*+/-6S→ IdoA2S→ GlcN2S→, the asterisk marking the target (symbols as in 2-Carb-38) using +/- to mean the presence or absence of a substituent, and > to separate a predominant structure from a minor one. Thus Glc(N2S > NAc) means a residue of glucosamine where the N carries a sulfo group mainly but occasionally an acetyl group.). It can also modify other precursor sequences within heparan sulfate but this action does not create functional antithrombin-binding sites. These precursors are variants of the consensus sequence: → Glc(N2S > NAc)+/-6S→ GlcA→ GlcN2S*+/-6S→ GlcA > IdoA+/-2S→ Glc(N2S/NAc)+/-6S→. If the heparan sulfate substrate lacks 2-O-sulfation of GlcA residues, then enzyme specificity is expanded to modify selected glucosamine residues preceded by IdoA as well as GlcA.

• Supplier: Creative Enzymes
• Product #: EXWM-3382
• CAS: 183257-54-7