Butein
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-16558-10 mM * 1 mL |
| CAS # | 487-52-5 |
| Pricing | 10 mM * 1 mL, USD $90.0 |
| Synonyms | 2’,3,4,4’-tetrahydroxy Chalcone |
| MWt | 272.25 |
| Formula | C₁₅H₁₂O₅ |
| Biological Activity | Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4[1]. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells[2]. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a[3]. Butein is a SIRT1 activator (STAC). |
| Purity | 99.95% |