GRAF1 Antibody

• Supplier: CD BioSciences
• Product #: AMA-0512
• Product Category: Antibodies
• Application: WB
• Product Usage Information Dilution: Western Blotting (1:1000)
• Reactivity: Human, Mouse, Rat
• Gene ID: 23092
• MW (Target): 92 kDa
• Storage: Store at -20°C. Do not aliquot the antibody.
• Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys261 of human GRAF1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
• Background: GTPase Regulator Associated with Focal Adhesion Kinase-1 (GRAF1), is a GTPase-activating protein for the small G proteins RhoA and Cdc42 It is composed of an N-terminal BAR domain, a PH domain, a RhoGAP domain, a proline-rich domain, and a C-terminal SH3 domain. GRAF1 contributes to the clathrin-independent carriers/GPI-enriched early endosomal compartments (CLIC/GEEC) pathway, and was the first specific protein component of this endocytic pathway to be discovered GRAF1 was identified as an important protein necessary for adeno-associated virus 2 infection In addition, research studies have linked GRAF1 to mental retardation skeletal muscle differentiation and myeloid leukemia.