HG-7-85-01
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-15814 |
| CAS # | 1258391-13-7 |
| Pricing | inquire |
| Biological Activity | HG-7-85-01 is a type II ATP competitive inhibitor of wild-type and gatekeeper mutations forms of Bcr-Abl, PDGFRα, Kit, and Src kinases. HG-7-85-01 inhibits T315I mutant Bcr-Abl kinase, KDR and RET with IC50s of 3 nM, 20 nM and 30 nM, and is only weak or no inhibition of other kinases (IC50>2 μM). HG-7-85-01 inhibits the cell proliferation, which is mediated by the induction of apoptosis, and inhibition of cell-cycle progression[1]. |
| MWt | 608.68 |
| Formula | C₃₁H₃₁F₃N₆O₂S |