Gö 6983, Free Base (Go 6983, Goe 6983, CAS 133053-19-7), >99%

LC Laboratories' Product Number G-7700 - Gö 6983, Free Base (Go 6983, Goe 6983, CAS 133053-19-7), >99% - for research use only. Gö 6983 is a potent, cell-permeable, ATP-competitive inhibitor of protein kinase C (PKC). It inhibited PKC isozymes with IC50 values of 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ. Gö 6983 weakly inhibited PKC[mu] with an IC50 of 20 µM. PKC inhibitors RO 31-8220 and Gö 6983 increased Akt phosphorylation and enhanced epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets. The aggregated form of Hsp27 in cultured cells became dissociated as a result of phosphorylation with various types of stress. Phorbol ester (PMA)-induced dissociation of Hsp27 was completely suppressed by staurosporine, Go 6983 and bisindolylmaleimide I, inhibitors of protein kinase C and partially suppressed by SB 203580 or PD 169316, inhibitors of p38 MAP kinase but not by PD 98059 and U0126, inhibitors of MAP kinase kinase (MEK).

• Supplier: LC Laboratories
• Product #: G-7700
• Sku #: G-7700_10mg