Gö 6983, Free Base (Go 6983, Goe 6983, CAS 133053-19-7), >99%

LC Laboratories' Product Number G-7700 - Gö 6983, Free Base (Go 6983, Goe 6983, CAS 133053-19-7), >99% - for research use only. Gö 6983 is a potent, cell-permeable, ATP-competitive inhibitor of protein kinase C (PKC). It inhibited PKC isozymes with IC50 values of 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ. Gö 6983 weakly inhibited PKC[mu] with an IC50 of 20 µM. PKC inhibitors RO 31-8220 and Gö 6983 increased Akt phosphorylation and enhanced epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets. The aggregated form of Hsp27 in cultured cells became dissociated as a result of phosphorylation with various types of stress. Phorbol ester (PMA)-induced dissociation of Hsp27 was completely suppressed by staurosporine, Go 6983 and bisindolylmaleimide I, inhibitors of protein kinase C and partially suppressed by SB 203580 or PD 169316, inhibitors of p38 MAP kinase but not by PD 98059 and U0126, inhibitors of MAP kinase kinase (MEK).
Supplier LC Laboratories
Product # G-7700
Sku # G-7700_10mg
Pricing 10 mg, $126.00
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