Polyethylene Glycol 1000

Ask supplier a question | View on supplier's website
Polyethylene glycol as being an addition polymer of ethylene oxide and water. Polyethylene glycol grades 200–600 are liquids; grades 1000 and above are solids at
ambient temperatures.
Liquid grades (PEG 200–600) occur as clear, colorless or slightly yellow-colored, viscous liquids. They have a slight but characteristic odor and a bitter, slightly burning taste. PEG 600 can occur as a solid at ambient temperatures.
Solid grades (PEG>1000) are white or off-white in color, and range in consistency from pastes to waxy flakes. They have a faint, sweet odor. Grades of PEG 6001 and above are available as free_x0002_flowing milled powders
Supplier CD Formulation
Product # PE-0669
Pricing , Inquire for price
product1 Humectants Excipients
Molecular Formula HOCH2(CH2OCH2)nCH2OH，n=20~23.
Applications Polyethylene glycols (PEGs) are widely used in a variety of pharmaceutical formulations, including parenteral, topical, ophthalmic, oral, and rectal preparations. Polyethylene glycol has been used experimentally in biodegradable polymeric matrices used in controlled-release systems.
Safety
  • LD50 (mouse, IP): 20g/kg;
  • LD50 (rat, IP): 15.6g/kg;
  • LD50 (rat, PO): 32g/kg.
Incompatibilities
  • The chemical reactivity of polyethylene glycols is mainly confined to the two terminal hydroxyl groups, which can be either esterified or etherified. However, all grades can exhibit some oxidizing activity owing to the presence of peroxide impurities and secondary products formed by autoxidation.
  • Liquid and solid polyethylene glycol grades may be incompatible with some coloring agents. The antibacterial activity of certain antibiotics is reduced in polyethylene glycol bases, particularly that of penicillin and bacitracin. The preservative efficacy of the parabens may also be impaired owing to binding with polyethylene glycols.
  • Physical effects caused by polyethylene glycol bases include softening and liquefaction in mixtures with phenol, tannic acid, and salicylic acid. Discoloration of sulfonamides and dithranol can also occur, and sorbitol may be precipitated from mixtures. Plastics, such as polyethylene, phenolformaldehyde, polyvinyl chloride, and cellulose-ester membranes (in filters) may be softened or dissolved by polyethylene glycols. Migration of polyethylene glycol can occur from tablet film coatings, leading to interaction with core components.
Synonyms Macrogol 1000
CAS Number 25322-68-3
Category Base; Humectants
UNII U076Q6Q621
Chemical Name Polyethylene Glycol 1000
Grade Pharmaceutical grade
Administration route Oral; Rectal; Topical; Vaginal; Transdermal
Dosage Form Solutions, suppositories, creams, gels, aerosol foams
Stability and Storage Conditions The freezing point is 30~40°C. Store in airtight container.
Commonly used amount and the maximum amount Generally, the maximum dosage of external preparations is 2mg/g.
Source and Preparation Polyethylene glycol polymers are formed by the reaction of ethylene oxide and water under pressure in the presence of a catalyst.
Feedback