PF-477736

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PF-477736 (PF-736, PF-00477736) is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM in a cell-free assay and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100-fold selectivity for Chk1 than Chk2.

Supplier	Selleck Chemicals
Product #	S2904
Sku #	S2904-10mM/1mL
Pricing	10mM/1mL, $250.00

Citations for this product:

Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1

Devashish Dwivedi, Daniela Harry, Patrick Meraldi, bioRxiv - Cell Biology 2022

Quote: ... Chk1: 1 µM PF-477736 (Selleck Chemicals: S2904), Chk2 ...

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