Tos-PEG4-t-butyl ester
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-130422-10 mM * 1 mL |
| CAS # | 217817-01-1 |
| Pricing | 10 mM * 1 mL, USD $55.0 |
| Biological Activity | Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM[1]. |
| Synonyms | Tos-PEG4-Boc |
| MWt | 432.53 |
| Formula | C₂₀H₃₂O₈S |