hypoxia-inducible factor-proline dioxygenase

Contains iron, and requires ascorbate. Specifically hydroxylates a proline residue in HIF-α, the α subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which targets HIF for proteasomal destruction.The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.

• Supplier: Creative Enzymes
• Product #: EXWM-0646