| Supplier |
Creative Peptides |
| Product # |
R0830 |
| CAS # |
514200-66-9 |
| Pricing |
Inquire
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| MolecularFormula |
C97H181N37O19
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| MolecularWeight |
2169.73
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| Sequence |
- One Letter Code: Ac-LRVRLASHLRKLRKRLL-NH2
- Three Letter Code: Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2
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| Storage |
Desiccate at -20°C
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| ShippingCondition |
Room temperature in continental US; may vary elsewhere.
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| Explanation |
COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC50 of 445 nM.
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| Solubility |
Soluble to 1 mg/ml in water
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| BiologicalActivity |
Apolipoprotein (ApoE) peptide fragment that functions via the low-density lipoprotein receptor-related protein (LRP). Substantially reduces the symptoms of experimental autoimmune encephalomyelitis, a model of human multiple sclerosis, and suppresses inflammation, demyelination and infiltration of cells into the spinal cord. Also acts as a non-competitive antagonist at α7 nicotinic acetylcholine receptors (IC50 = 445 nM).
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