ACY-738
ACY-738 is a potent and selective HDAC6 inhibitor with improved brain bioavailability. ACY-738 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. ACY-738 induces dramatic increases in α-tubulin acetylation in brain and stimulate mouse exploratory behaviors in novel, but not familiar environments.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD651 |
| CAS # | 1375465-91-0 |
| Pricing | Customizable size, Inquiry |
| Synonym | ACY-738; ACY 738; ACY738. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C14H14N4O2 |
| Exact Mass | 270.1117 |
| Molecular Weight | 270.292 |
| Elemental Analysis | C, 62.21; H, 5.22; N, 20.73; O, 11.84 |
| IUPAC/Chemical Name | N-Hydroxy-2-[(1-phenylcyclopropyl)amino]-5-pyrimidinecarboxamide |
| InChi Key | LIIWIMDSZVNYHY-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C14H14N4O2/c19-12(18-20)10-8-15-13(16-9-10)17-14(6-7-14)11-4-2-1-3-5-11/h1-5,8-9,20H,6-7H2,(H,18,19)(H,15,16,17) |
| SMILES Code | O=C(C1=CN=C(NC2(C3=CC=CC=C3)CC2)N=C1)NO |
| Appearance | White to off-white solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |