Laduviglusib (CHIR-99021) HCl
Laduviglusib (CHIR-99021; CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of the Wnt/beta-catenin signaling pathway. CHIR-99021 significantly rescues light-induced autophagy and augments GR, RORα and autophagy-related proteins.
| Supplier | Selleck Chemicals |
|---|---|
| Product # | S2924 |
| Sku # | S2924-25mg |
| Pricing | 25mg, $570.00 |
Citations for this product:
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bioRxiv - Cell Biology 2021Quote: ... and glycogen synthase kinase-3β (1 µM; CHIR99021, Cat#S2924; Selleck Chemicals), collectively termed LIF2i ...
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bioRxiv - Neuroscience 2021Quote: ... 3 μM CHIR99021 (Selleck Chemicals; Houston, TX, USA; Cat. No. S2924), 2 μM DMH1 (Selleck Chemicals ...
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bioRxiv - Cancer Biology 2022Quote: ... and CHIR-99021 (#S2924) were from Selleck Chemicals, USA ...
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bioRxiv - Biophysics 2023Quote: ... hiPSCs were treated with 8 μM CHIR-99021 (Selleck Chemicals, S2924) for 2 days ...
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bioRxiv - Developmental Biology 2022Quote: ... and 3uM CHIR-99021 (Selleck Chemicals S2924).
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bioRxiv - Molecular Biology 2022Quote: ... and 3uM CHIR-99021 (Selleck Chemicals, S2924). CNCCs were then passaged twice to passage 4 and processed for various assays.