Lisavanbulin HCl
Lisavanbulin HCl, also known as BAL-101553, is an orally available, highly water-soluble lysine prodrug of the synthetic small molecule BAL-27862 with potential antitumor activity. Upon administration of BAL101553 and conversion into the active form BAL-27862, this agent binds to tubulin at a site distinct from the vinca-alkaloid-binding site, and prevents tubulin polymerization and destabilizes microtubules, ultimately leading to cell cycle arrest, blockage of cell division and an induction of cell death in cancer cells.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD571 |
| CAS # | 1387574-54-0 (HCl) |
| Pricing | Customizable size, Inquiry |
| Synonym | Lisavanbulin dihydrochloride; Lisavanbulin HCl; BAL-101553 dihydrochloride; BAL 101553 dihydrochloride; BAL101553 dihydrochloride; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C26H31Cl2N9O3 |
| Exact Mass | 587.1927 |
| Molecular Weight | 588.49 |
| Elemental Analysis | C, 53.07; H, 5.31; Cl, 12.05; N, 21.42; O, 8.16 |
| IUPAC/Chemical Name | (S)-2,6-diamino-N-(4-(2-(2-(4-((2-cyanoethyl)amino)-1,2,5-oxadiazol-3-yl)-1H-benzo[d]imidazol-1-yl)acetyl)phenyl)hexanamide dihydrochloride |
| InChi Key | AOKATNWVGVIXOQ-TXEPZDRESA-N |
| InChi Code | InChI=1S/C26H29N9O3.2ClH/c27-13-4-3-6-19(29)26(37)31-18-11-9-17(10-12-18)22(36)16-35-21-8-2-1-7-20(21)32-25(35)23-24(34-38-33-23)30-15-5-14-28;;/h1-2,7-12,19H,3-6,13,15-16,27,29H2,(H,30,34)(H,31,37);2*1H/t19-;;/m0../s1 |
| SMILES Code | O=C(NC1=CC=C(C(CN2C(C3=NON=C3NCCC#N)=NC4=CC=CC=C24)=O)C=C1)[C@@H](N)CCCCN.[H]Cl.[H]Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |