TAK-243 (MLN7243)
TAK-243 (MLN7243) is a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE) with an IC50 of 1 ± 0.2 nM in the UBCH10 E2 thioester assay. It has minimal inhibitory activity in a panel of kinase and receptor assays, as well as on human carbonic anhydrase type I and type II. TAK-243 (MLN7243) induces ER stress, abrogates NFκB pathway activation and promotes apoptosis.
Supplier | Selleck Chemicals |
---|---|
Product # | S8341 |
Sku # | S8341-5mg |
Pricing | 5mg, $190.00 |
Citations for this product:
-
bioRxiv - Cancer Biology 2024Quote: ... and TAK-243 (also known as MLN7243, Selleck Chemicals S8341) at 0.1 μM ...