HS 014 acetate
HS 014 acetate is a potent and selective melanocortin MC4 receptor antagonist with Kis of 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors, respectively. HS 014 promotes food intake in rats and nociception in mice following central administration in vivo. HS 014 also inhibits IL-1β-induced Fos expression in the paraventricular hypothalamus.
| Supplier | BOC Sciences |
|---|---|
| Product # | BAT-016375 |
| Pricing | Inquire |
| Molecular Weight | 1623.83 |
| Molecular Formula | C73H98N20O19S2 |
| Canonical SMILES | CC(=O)NC1CSSCC(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCC(=O)O)CC2=CNC=N2)CC3=CC4=CC=CC=C4C=C3)CCCNC(=N)N)CC5=CNC6=CC=CC=C65)C(=O)N7CCCC7C(=O)N8CCCC8C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)N.CC(=O)O |