Human Anti-CD27 Recombinant Antibody (clone mAb 2177); Fab Fragment

This product is a recombinant Human antibody Fab fragment that can recognize CD27. mAb 2177 does not block the binding of the soluble form of the ligand, sCD70. It does however neutralize the cell-bound form of CD70, most likely by steric interference owing to its placement on top of the receptor chain. The mAb to sterically block the cell-bound form of CD70 from reaching CD27 while leaving the ligand epitope clear. This mode of action suggests a potential dual use of mAb 2177 either as an antagonist or as an agonist.

• Supplier: Creative Biolabs
• Product #: PFBC-463
• Host: Human
• Target: CD27
• Species Reactivity: Human
• Type: Human Fab
• Applications: ELISA, FC, Antagonist, Agonist
• Storage: Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.