TMI 1
TMI 1 is a dual inhibitor of Adam 17 (TACE) and MMP inhibitor (IC50 = 3, 4.7, 6.6, 8.4, 12, 26 and 26 nM for MMP-13, MMP-2, MMP-1, ADAM 17, MMP-9, MMP-7 and MMP-14, respectively). TMI 1 suppresses TNF-α production in an acute LPS-mouse model. TMI 1 exhibits selective cytotoxicity to tumor cells and cancer stem cells in vitro, and induces apoptosis in a breast cancer in vivo model.
| Supplier | BOC Sciences |
|---|---|
| Product # | 287403-39-8 |
| Pricing | Inquire |
| Cas | 287403-39-8 |
| Molecular Weight | 398.49 |
| Molecular Formula | C17H22N2O5S2 |
| Canonical SMILES | CC#CCOC1=CC=C(C=C1)S(=O)(=O)N2CCSC(C2C(=O)NO)(C)C |