Rapastinel acetate
Rapastinel, also known as GLYX-13 and BV-102, is a novel antidepressant drug approved as an adjunctive therapy for the treatment of treatment-resistant major depressive disorder. It is a centrally active, intravenously administered (non-orally active) amidated tetrapeptide (Thr-Pro-Pro-Thr-NH2) that acts as a selective, weak partial agonist (mixed antagonist/agonist) of an allosteric site at the glycine site of the NMDA receptor complex (Emax ≈ 25%).[1][2] The drug is a rapid-acting and long-lasting antidepressant as well as robust cognitive enhancer by virtue of its ability to both inhibit and enhance NMDA receptor-mediated signal transduction.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1133 |
| CAS # | 491872-39-0 (acetate) |
| Pricing | Customizable size, Inquiry |
| Synonym | Rapastinel acetate; GLYX-13; GLYX 13; GLYX13; BV-102; BV102; BV 102; TPPT-amide; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C20H35N5O8 |
| Exact Mass | 473.2486 |
| Molecular Weight | 473.527 |
| Elemental Analysis | C, 50.73; H, 7.45; N, 14.79; O, 27.03 |
| IUPAC/Chemical Name | L-Threoninamide, L-threonyl-L-prolyl-L-prolyl-, monoacetate |
| InChi Key | MNEQLJKNUQMKNP-GDLIIDCZSA-N |
| InChi Code | InChI=1S/C18H31N5O6.C2H4O2/c1-9(24)13(19)18(29)23-8-4-6-12(23)17(28)22-7-3-5-11(22)16(27)21-14(10(2)25)15(20)26;1-2(3)4/h9-14,24-25H,3-8,19H2,1-2H3,(H2,20,26)(H,21,27);1H3,(H,3,4)/t9-,10-,11+,12+,13+,14+;/m1./s1 |
| SMILES Code | C[C@@H](O)[C@@H](C(N)=O)NC([C@H]1N(C([C@H]2N(C([C@H]([C@H](O)C)N)=O)CCC2)=O)CCC1)=O.CC(O)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |